Ọja: 2-phenylacetamide
Ilana molikula: C8H9NO
iwuwo molikula: 135.17
Orukọ Gẹẹsi: Phenylacetamide
Ohun kikọ: Flake funfun tabi awọn kirisita ti o ni apẹrẹ ewe.Mp 157-158 ℃, bp 280-290 ℃ (gbigba).Tiotuka ninu omi gbigbona ati ethanol, tiotuka diẹ ninu omi tutu, ether, ati benzene.
Lilo: Agbedemeji awọn oogun bii penicillin ati phenobarbital.O tun lo fun igbaradi ti phenylacetic acid, turari, ati awọn ipakokoropaeku.
Ọna 1) Masuko F， Katsura T.US 4536599A1.1985.
Fi 117.2 g (1.0 mol) ti phenylacetonitrile (2), 56.1 g ti 25% potasiomu hydroxide ojutu, 291.5 g ti 35% hydrogen peroxide ojutu olomi, 1.78 g ti benzyltriethylammonium kiloraidi, ati 351.5 g ti isopropanol si esi ti flapanol.Aruwo ati fesi ni 50 ℃ fun wakati 4.Lẹhin ti iṣeduro ti pari, isopropanol ti wa ni evaporated labẹ titẹ dinku, tutu, filtered, fo pẹlu omi, ati ki o gbẹ lati gba yellow (1) 128.5 g, mp 155 ℃, pẹlu ikore ti 95%.
Ọna 2) Furniss BS, Hannaford AJ, Rogers V, et al.Vogel's Textbook of Practical Chemistry.Longman London ati New York.Ẹda kẹrin,1978：518.
Fi 100 g (0.85 mol) ti phenylacetonitrile (2) ati 400 milimita ti ogidi hydrochloric acid si ọpọn ifasẹyin.Labẹ igbiyanju, fesi ni 40 ℃ fun iṣẹju 40, ki o si gbe iwọn otutu soke si 50 ℃.Tesiwaju lati fesi fun ọgbọn išẹju 30.Dara si 15 ℃ ki o fi 400 milimita ti omi distilled tutu silẹ.Itutu ninu iwẹ omi yinyin, sisẹ awọn kirisita.Fi ohun ti o lagbara si 50 milimita ti omi ki o si rọra daradara lati yọ phenylacetic acid kuro.Ajọ ati ki o gbẹ ni 50-80 ℃ lati gba 95 g phenylacetamide (1), mp 154-155 ℃, pẹlu ikore ti 82%.Atunse pẹlu ethanol, mp 156 ℃.
Akoko ifiweranṣẹ: Oṣu Kẹrin Ọjọ 11-2023